Patients:

Inclusion Criteria:

• DSM-IV schizophrenia

Exclusion Criteria:

• Other current DSM-IV axis I diagnosis
• Serious untreated medical illness
• Loss of consciousness>30 minutes with neurological sequelae
• Drug abuse or dependence within 3 months prior to study
• Unable to hear spoken language

Healthy Controls:

Exclusion Criteria:

• Any head trauma with loss of consciousness
• Drug abuse/dependence within the last six months
• Hearing or vision loss
• Untreated medical illness
• Current psychiatric disorder

What Will Subjects Do?

We are using event-related brain potentials (ERPs), a temporally sensitive functional brain imaging tool, to record neural responses to auditory and visual stimuli presented during both naturalistic and mimicked hallucinations. In parallel experiments, we are also using functional magnetic resonance imaging (fMRI) to measure cortical activation. The ERPs will be recorded at the VA hospital and fMRI will be collected at Lucas Center on Campus. Clinical interviews (SCID) and ratings (BPRS, SANS, SAPS, all done in person) will be done on patients. SCID telephone screen will be done on controls. No clinical ratings for controls.

Subjects Needed:

Characteristic Subjects: 50

Healthy Subjects: 50

If you would like to participate in this study, whether or not you think you qualify, please click the Sign Up button below, and let us know of your interest.